Abstract
Background
Previous literature on the determinants of diaphragm dysfunction in septic patients
is limited. The goal of this study is to assess diaphragm dysfunction in terms of
its prevalence and its potential associated factors in septic intensive care unit
(ICU) patients.
Methods
This prospective and observational study was conducted between June 2015 and July
2019. Ultrasound measures of diaphragm thickness were performed daily on septic patients.
The primary outcome was the prevalence of diaphragm dysfunction at baseline and during
the ICU stay. The secondary outcome was the diaphragm thickness. Possible associated
factors were prospectively recorded.
Results
Fifty patients were enrolled in the study. The prevalence of diaphragm dysfunction
was 58%. No diaphragm atrophy was found during the ICU stay. Diaphragm dysfunction
was associated with the alteration of consciousness, intra-abdominal sepsis, hypnotics
and opioids, and mechanical ventilation. Administration of hypnotics, opioids, and
steroids was associated with a decreased diaphragm thickening fraction. Diaphragm
dysfunction had no impact on patient outcomes.
Conclusions
Our data reveal a high prevalence of diaphragm dysfunction in septic patients at the
onset of sepsis. Administration of hypnotics, opioids, and steroids was associated
with the alteration of diaphragm function as well as intra-abdominal sepsis.
Keywords
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Article Info
Publication History
Published online: March 08, 2022
Accepted:
January 13,
2022
Received in revised form:
December 23,
2021
Received:
August 28,
2021
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Australian College of Critical Care Nurses Ltd. Published by Elsevier Ltd. All rights reserved.
